Live tularemia vaccine confers protection against lethal Legionella and Listeria infections in experimental animals

YF Belyi, IS Tartakovskii… - FEMS Immunology & …, 1996 - academic.oup.com
YF Belyi, IS Tartakovskii, IS Mesheryakova, VV Petrosov, SV Prosorovskii
FEMS Immunology & Medical Microbiology, 1996academic.oup.com
The efficacy of a live Francisella tularensis vaccine strain to cause nonspecific immunity
toward experimental legionellosis and listeriosis was studied. Immunisation with tularemia
vaccine protected over 80% and 17% of experimental animals against subsequent lethal
challenge with Legionella pneumophila and Listeria monocytogenes, respectively. The
protection was maximal during the first month following immunisation and declined
thereafter. In order to delineate the immunostimulatory moieties of the Francisella microbe …
Abstract
The efficacy of a live Francisella tularensis vaccine strain to cause nonspecific immunity toward experimental legionellosis and listeriosis was studied. Immunisation with tularemia vaccine protected over 80% and 17% of experimental animals against subsequent lethal challenge with Legionella pneumophila and Listeria monocytogenes, respectively. The protection was maximal during the first month following immunisation and declined thereafter. In order to delineate the immunostimulatory moieties of the Francisella microbe, several cell wall proteins have been purified and characterized. However, isolated cell wall components failed to induce protection.
Oxford University Press
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